Motif ID: SOX{8,9,10}.p2

Z-value: 1.539


Transcription factors associated with SOX{8,9,10}.p2:

Gene SymbolEntrez IDGene Name
SOX10 6663 SRY (sex determining region Y)-box 10
SOX8 30812 SRY (sex determining region Y)-box 8
SOX9 6662 SRY (sex determining region Y)-box 9

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SOX9chr17_+_676287720.458.0e-02Click!
SOX10chr22_-_367104840.204.5e-01Click!


Activity profile for motif SOX{8,9,10}.p2.

activity profile for motif SOX{8,9,10}.p2


Sorted Z-values histogram for motif SOX{8,9,10}.p2

Sorted Z-values for motif SOX{8,9,10}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX{8,9,10}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_128883125 4.429 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chr7_-_27171673 3.545 NM_152739
HOXA9
homeobox A9
chr12_-_8706533 3.494 MFAP5
microfibrillar associated protein 5
chr7_-_27171648 3.252 HOXA9
homeobox A9
chr17_-_36996611 3.038 NM_000526
KRT14
keratin 14
chr12_-_51173238 2.619 NM_005554
KRT6A
keratin 6A
chr12_-_8706637 2.529 NM_003480
MFAP5
microfibrillar associated protein 5
chr2_+_101680594 2.489 NM_004834
NM_145686
NM_145687
MAP4K4


mitogen-activated protein kinase kinase kinase kinase 4


chr21_+_17807167 2.160 NM_001338
CXADR
coxsackie virus and adenovirus receptor
chr11_-_27450808 1.964 NM_018490
LGR4
leucine-rich repeat containing G protein-coupled receptor 4
chr1_-_43196911 1.923 SLC2A1
solute carrier family 2 (facilitated glucose transporter), member 1
chr5_-_16989371 1.911 NM_012334
MYO10
myosin X
chr1_-_94475504 1.878 ARHGAP29
Rho GTPase activating protein 29
chr12_+_52665196 1.727 NM_017409
HOXC10
homeobox C10
chr7_+_134114957 1.711 CALD1
caldesmon 1
chr1_-_95165037 1.704 CNN3
calponin 3, acidic
chr7_+_121300394 1.633 NM_002851
PTPRZ1
protein tyrosine phosphatase, receptor-type, Z polypeptide 1
chr10_+_71482362 1.594 NM_018649
H2AFY2
H2A histone family, member Y2
chr10_+_71482542 1.571 H2AFY2
H2A histone family, member Y2
chr4_-_186969041 1.570 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chr10_-_105835609 1.556 NM_000494
COL17A1
collagen, type XVII, alpha 1
chr1_+_151270301 1.509 NM_003125
SPRR1B
small proline-rich protein 1B
chr1_-_117011824 1.508 NM_001007237
NM_001542
IGSF3

immunoglobulin superfamily, member 3

chr8_-_29262240 1.454 NM_057158
DUSP4
dual specificity phosphatase 4
chr16_+_81218074 1.426 NM_001257
CDH13
cadherin 13, H-cadherin (heart)
chr12_-_8706746 1.415 MFAP5
microfibrillar associated protein 5
chr3_-_187309442 1.388 NM_004454
ETV5
ets variant 5
chrX_-_37964924 1.384 NM_001170750
NM_001170751
NM_001170752
NM_006307
SRPX



sushi-repeat containing protein, X-linked



chr3_-_151171576 1.371 PFN2
profilin 2
chr12_-_94135154 1.368 NM_018351
FGD6
FYVE, RhoGEF and PH domain containing 6
chr6_-_10523424 1.270 NM_003220
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr1_-_43197123 1.269 SLC2A1
solute carrier family 2 (facilitated glucose transporter), member 1
chr10_-_105835525 1.266 COL17A1
collagen, type XVII, alpha 1
chr9_-_73573121 1.236 NM_001135820
NM_013390
TMEM2

transmembrane protein 2

chr4_+_74491272 1.219 ALB
albumin
chr1_+_93686154 1.202 NM_001024948
NM_001164473
NM_017737
FNBP1L


formin binding protein 1-like


chr4_-_186969202 1.178 NM_001145671
SORBS2
sorbin and SH3 domain containing 2
chr11_+_129496792 1.170 APLP2
amyloid beta (A4) precursor-like protein 2
chr5_+_50714996 1.145 ISL1
ISL LIM homeobox 1
chr20_-_55718982 1.141 NM_199169
NM_199170
PMEPA1

prostate transmembrane protein, androgen induced 1

chr5_+_148186348 1.141 NM_000024
ADRB2
adrenergic, beta-2-, receptor, surface
chr17_+_39778191 1.116 GRN
granulin
chr17_-_37196463 1.105 NM_002230
NM_021991
JUP

junction plakoglobin

chr2_-_151052391 1.099 NM_005168
RND3
Rho family GTPase 3
chr3_-_150578023 1.086 TM4SF1
transmembrane 4 L six family member 1
chr8_-_119192985 1.084 NM_000127
EXT1
exostosin 1
chr7_+_16759845 1.078 NM_014399
TSPAN13
tetraspanin 13
chr20_-_17610828 1.076 NM_001042576
NM_004587
RRBP1

ribosome binding protein 1 homolog 180kDa (dog)

chr14_+_85066207 1.066 NM_013231
FLRT2
fibronectin leucine rich transmembrane protein 2
chr4_-_7991992 1.051 NM_001134647
NM_198595
AFAP1

actin filament associated protein 1

chr7_-_107430566 1.045 NM_002291
LAMB1
laminin, beta 1
chr11_+_101488380 1.032 NM_001195045
YAP1
Yes-associated protein 1
chr18_+_3439972 1.015 NM_173209
NM_173208
NM_003244
TGIF1


TGFB-induced factor homeobox 1


chr17_+_39778180 1.015 GRN
granulin
chr1_-_223907283 1.013 NM_001008493
NM_018212
ENAH

enabled homolog (Drosophila)

chr4_-_40631397 1.012 APBB2
amyloid beta (A4) precursor protein-binding, family B, member 2
chr14_+_85066265 0.993 FLRT2
fibronectin leucine rich transmembrane protein 2
chr4_+_78297356 0.986 NM_004354
CCNG2
cyclin G2
chr1_-_85703198 0.969 DDAH1
dimethylarginine dimethylaminohydrolase 1
chr18_+_3437607 0.961 NM_173207
TGIF1
TGFB-induced factor homeobox 1
chr1_-_94475840 0.958 NM_004815
ARHGAP29
Rho GTPase activating protein 29
chr1_-_153213454 0.955 SHC1
SHC (Src homology 2 domain containing) transforming protein 1
chr4_+_75529716 0.951 NM_001657
AREG
amphiregulin
chr4_-_15549047 0.947 NM_005130
FGFBP1
fibroblast growth factor binding protein 1
chr15_+_37660568 0.946 NM_003246
THBS1
thrombospondin 1
chr1_-_95165089 0.943 NM_001839
CNN3
calponin 3, acidic
chr18_+_3441589 0.941 NM_170695
NM_173210
TGIF1

TGFB-induced factor homeobox 1

chr16_-_30841938 0.940 NCRNA00095
non-protein coding RNA 95
chrX_+_105823723 0.938 NM_024539
RNF128
ring finger protein 128
chr17_+_39778153 0.938 GRN
granulin
chr6_+_114285209 0.925 NM_002356
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr16_+_8714326 0.914 NM_000663
ABAT
4-aminobutyrate aminotransferase
chr8_+_26491317 0.910 NM_001386
DPYSL2
dihydropyrimidinase-like 2
chr3_+_195336625 0.910 NM_005524
HES1
hairy and enhancer of split 1, (Drosophila)
chr18_+_53862386 0.894 NM_001144967
NM_015277
NEDD4L

neural precursor cell expressed, developmentally down-regulated 4-like

chr22_-_17892859 0.891 NM_001130861
NM_003277
CLDN5

claudin 5

chr15_+_38923914 0.887 NM_001032367
SPINT1
serine peptidase inhibitor, Kunitz type 1
chr17_-_35464137 0.886 MED24
mediator complex subunit 24
chr7_+_77005287 0.885 NM_001131008
NM_001131009
PTPN12

protein tyrosine phosphatase, non-receptor type 12

chr1_-_153213483 0.877 NM_001130041
NM_003029
SHC1

SHC (Src homology 2 domain containing) transforming protein 1

chr18_+_54039779 0.871 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr8_+_95722516 0.868 NM_001034915
NM_001122825
NM_001122826
NM_001122827
NM_017697
ESRP1




epithelial splicing regulatory protein 1




chr2_+_9264360 0.857 ASAP2
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
chr8_+_95722575 0.849 ESRP1
epithelial splicing regulatory protein 1
chr1_-_153213425 0.847 SHC1
SHC (Src homology 2 domain containing) transforming protein 1
chr2_-_239987557 0.847 NM_006037
HDAC4
histone deacetylase 4
chr4_+_78297418 0.839 CCNG2
cyclin G2
chr7_-_27102049 0.822 NM_005522
NM_153620
HOXA1

homeobox A1

chr7_-_27186400 0.819 NM_153715
HOXA10
homeobox A10
chr1_-_27871306 0.817 NM_002038
NM_022872
NM_022873
IFI6


interferon, alpha-inducible protein 6


chr7_+_18501876 0.805 NM_014707
NM_178423
HDAC9

histone deacetylase 9

chr3_-_150422474 0.804 NM_000096
CP
ceruloplasmin (ferroxidase)
chr5_-_125958503 0.800 NM_001182
ALDH7A1
aldehyde dehydrogenase 7 family, member A1
chr12_-_6103945 0.798 NM_000552
VWF
von Willebrand factor
chr18_+_54039818 0.795 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr20_+_29656744 0.795 NM_002165
NM_181353
ID1

inhibitor of DNA binding 1, dominant negative helix-loop-helix protein

chr10_-_123346148 0.792 NM_001144915
FGFR2
fibroblast growth factor receptor 2
chr17_-_1566223 0.778 C17orf91
chromosome 17 open reading frame 91
chr15_+_97009194 0.774 IGF1R
insulin-like growth factor 1 receptor
chr11_+_131285747 0.772 NM_001144058
NM_001144059
NM_016522
NTM


neurotrimin


chr5_+_50714714 0.769 NM_002202
ISL1
ISL LIM homeobox 1
chr7_-_111633620 0.766 NM_014705
DOCK4
dedicator of cytokinesis 4
chr6_-_2785682 0.758 SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr4_+_78298326 0.758 CCNG2
cyclin G2
chr1_+_26376560 0.754 NM_006314
CNKSR1
connector enhancer of kinase suppressor of Ras 1
chr3_+_189354167 0.753 NM_001167672
LPP
LIM domain containing preferred translocation partner in lipoma
chr19_+_40298571 0.734 NM_001136007
NM_001136008
NM_001136009
NM_001136010
NM_001136011
NM_001136012
NM_005971
NM_021910
FXYD3







FXYD domain containing ion transport regulator 3







chr3_+_51397731 0.729 NM_006010
MANF
mesencephalic astrocyte-derived neurotrophic factor
chr6_-_11340886 0.728 NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr1_-_68470585 0.719 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr14_+_58725104 0.717 NM_014992
DAAM1
dishevelled associated activator of morphogenesis 1
chr3_+_51397756 0.715 MANF
mesencephalic astrocyte-derived neurotrophic factor
chr18_+_11741470 0.714 NM_001142339
NM_002071
GNAL

guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type

chr8_+_102573837 0.714 NM_024915
GRHL2
grainyhead-like 2 (Drosophila)
chr20_+_60918836 0.713 NM_001853
COL9A3
collagen, type IX, alpha 3
chr8_-_81155564 0.700 NM_001025252
TPD52
tumor protein D52
chr5_+_40715778 0.699 NM_000958
PTGER4
prostaglandin E receptor 4 (subtype EP4)
chr1_+_167342149 0.693 ATP1B1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr17_+_43480674 0.685 NM_003204
NFE2L1
nuclear factor (erythroid-derived 2)-like 1
chr3_+_195336631 0.685 HES1
hairy and enhancer of split 1, (Drosophila)
chr4_+_146623405 0.674 NM_001003688
SMAD1
SMAD family member 1
chr20_-_17610704 0.671 RRBP1
ribosome binding protein 1 homolog 180kDa (dog)
chr3_+_189425886 0.664 NM_001167671
LPP
LIM domain containing preferred translocation partner in lipoma
chr16_-_88084387 0.662 NM_013275
ANKRD11
ankyrin repeat domain 11
chr6_+_121798443 0.660 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr10_-_97311084 0.644 NM_015385
NM_024991
SORBS1

sorbin and SH3 domain containing 1

chr18_+_54039730 0.642 NM_001144966
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr17_+_43480723 0.642 NFE2L1
nuclear factor (erythroid-derived 2)-like 1
chr18_-_72857665 0.633 MBP
myelin basic protein
chr19_+_38556414 0.630 NM_001806
CEBPG
CCAAT/enhancer binding protein (C/EBP), gamma
chr11_+_60448487 0.625 NM_017870
NM_178031
TMEM132A

transmembrane protein 132A

chr10_+_73393998 0.623 NM_004273
CHST3
carbohydrate (chondroitin 6) sulfotransferase 3
chr9_-_74757735 0.618 NM_000689
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr8_+_26491383 0.608 DPYSL2
dihydropyrimidinase-like 2
chr10_+_73703682 0.606 NM_019058
DDIT4
DNA-damage-inducible transcript 4
chr10_+_5126589 0.606 AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr15_+_38923470 0.602 NM_003710
NM_181642
SPINT1

serine peptidase inhibitor, Kunitz type 1

chr12_-_31370387 0.597 NM_001135811
NM_021238
NM_001135812
FAM60A


family with sequence similarity 60, member A


chr15_-_80428760 0.595 NM_001164465
GOLGA6L10
golgin A6 family-like 10
chr6_-_134680888 0.582 NM_001143676
SGK1
serum/glucocorticoid regulated kinase 1
chr10_+_5126556 0.581 NM_003739
AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr1_+_85819004 0.578 NM_001554
CYR61
cysteine-rich, angiogenic inducer, 61
chr2_+_9264327 0.576 NM_001135191
NM_003887
ASAP2

ArfGAP with SH3 domain, ankyrin repeat and PH domain 2

chr12_-_31370351 0.575 FAM60A
family with sequence similarity 60, member A
chr16_-_21344158 0.572 NM_130464
NPIPL3
nuclear pore complex interacting protein-like 3
chr9_-_14388981 0.571 NM_001190738
NFIB
nuclear factor I/B
chr5_+_74668748 0.571 NM_000859
NM_001130996
HMGCR

3-hydroxy-3-methylglutaryl-CoA reductase

chr3_-_140741221 0.570 NM_001130992
NM_001130993
NM_002899
RBP1


retinol binding protein 1, cellular


chr9_-_35101534 0.569 KIAA1539
KIAA1539
chr10_+_5126613 0.569 AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr11_-_116213511 0.562 NM_000039
APOA1
apolipoprotein A-I
chr16_+_22432344 0.560 NM_001135865
LOC100132247
NPIPL3
nuclear pore complex interacting protein related gene
nuclear pore complex interacting protein-like 3
chr10_-_33287184 0.555 NM_002211
ITGB1
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
chr8_+_94998258 0.555 NM_018444
NM_001161780
NM_001161779
NM_001161781
PDP1



pyruvate dehyrogenase phosphatase catalytic subunit 1



chr12_-_31370305 0.553 FAM60A
family with sequence similarity 60, member A
chr17_-_35464414 0.551 NM_001079518
NM_014815
MED24

mediator complex subunit 24

chr11_-_74914514 0.547 GDPD5
glycerophosphodiester phosphodiesterase domain containing 5
chr14_+_23008742 0.547 NGDN
neuroguidin, EIF4E binding protein
chr10_+_102096761 0.545 NM_005063
SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr16_-_4927057 0.542 NM_002705
PPL
periplakin
chr3_-_101077605 0.539 NM_014890
FILIP1L
filamin A interacting protein 1-like
chr1_-_203557379 0.538 NM_030952
NUAK2
NUAK family, SNF1-like kinase, 2
chr1_+_109221124 0.535 NM_013296
GPSM2
G-protein signaling modulator 2
chrX_+_102498035 0.534 NM_001006612
NM_001006613
NM_001006614
NM_016303
WBP5



WW domain binding protein 5



chr8_+_95722448 0.534 ESRP1
epithelial splicing regulatory protein 1
chr1_+_109221271 0.530 GPSM2
G-protein signaling modulator 2
chr7_+_134114912 0.529 CALD1
caldesmon 1
chr11_+_13255836 0.529 NM_001030272
NM_001030273
NM_001178
ARNTL


aryl hydrocarbon receptor nuclear translocator-like


chr2_-_39517633 0.528 NM_003618
MAP4K3
mitogen-activated protein kinase kinase kinase kinase 3
chr3_+_190831909 0.522 NM_001114978
NM_001114979
NM_003722
TP63


tumor protein p63


chr1_+_198975227 0.520 NM_203459
CAMSAP1L1
calmodulin regulated spectrin-associated protein 1-like 1
chr2_+_64534774 0.515 NM_014181
HSPC159
galectin-related protein
chr11_-_66482366 0.512 NM_000920
NM_001040716
PC

pyruvate carboxylase

chr3_-_57558120 0.510 ARF4
ADP-ribosylation factor 4
chr11_+_13255913 0.510 ARNTL
aryl hydrocarbon receptor nuclear translocator-like
chr19_-_60352369 0.507 NM_001126132
NM_001126133
NM_003283
TNNT1


troponin T type 1 (skeletal, slow)


chr14_+_23008723 0.506 NM_001042635
NM_015514
NGDN

neuroguidin, EIF4E binding protein

chr3_-_57558130 0.505 ARF4
ADP-ribosylation factor 4
chr16_+_28869628 0.504 NM_032815
NFATC2IP
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein
chr4_-_187114407 0.504 SORBS2
sorbin and SH3 domain containing 2
chr7_-_41709191 0.503 NM_002192
INHBA
inhibin, beta A
chr17_+_43480724 0.499 NFE2L1
nuclear factor (erythroid-derived 2)-like 1
chr10_+_124211353 0.497 HTRA1
HtrA serine peptidase 1
chr3_-_11598829 0.494 NM_001128220
VGLL4
vestigial like 4 (Drosophila)
chr12_-_10142779 0.492 NM_016511
CLEC1A
C-type lectin domain family 1, member A
chr2_-_160765008 0.492 ITGB6
integrin, beta 6
chr2_-_131838200 0.492 NM_001077637
LOC150786
RAB6C-like
chr1_+_67923660 0.491 GADD45A
growth arrest and DNA-damage-inducible, alpha
chr6_+_158653679 0.487 NM_001007466
NM_020245
TULP4

tubby like protein 4

chr16_+_64958025 0.484 NM_001795
CDH5
cadherin 5, type 2 (vascular endothelium)
chr20_-_45418818 0.484 NM_012408
NM_183047
NM_183048
ZMYND8


zinc finger, MYND-type containing 8


chrX_+_149902415 0.484 NM_005342
HMGB3
high-mobility group box 3
chr3_-_51976428 0.477 NM_020418
NM_001174100
NM_033008
PCBP4


poly(rC) binding protein 4


chr1_-_150564302 0.474 NM_002016
FLG
filaggrin
chr22_+_31527678 0.473 TIMP3
TIMP metallopeptidase inhibitor 3
chr16_-_83095720 0.473 NM_020947
KIAA1609
KIAA1609
chr11_-_128567302 0.469 NM_001142685
ARHGAP32
Rho GTPase activating protein 32
chr22_+_36472262 0.466 TRIOBP
TRIO and F-actin binding protein
chr13_-_40138607 0.466 NM_002015
FOXO1
forkhead box O1
chr3_-_57557906 0.466 ARF4
ADP-ribosylation factor 4

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.26 6.47e-06 GO:0032501 multicellular organismal process
1.32 1.75e-05 GO:0007275 multicellular organismal development
1.30 2.41e-05 GO:0032502 developmental process
1.32 1.10e-04 GO:0048856 anatomical structure development
2.17 4.13e-04 GO:0030029 actin filament-based process
1.32 4.62e-04 GO:0048731 system development
6.66 1.13e-02 GO:0003009 skeletal muscle contraction
2.52 1.37e-02 GO:0007156 homophilic cell adhesion
1.41 1.50e-02 GO:0007399 nervous system development
2.08 1.54e-02 GO:0030036 actin cytoskeleton organization

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.72 1.41e-03 GO:0030054 cell junction
1.84 2.20e-02 GO:0015629 actin cytoskeleton
1.20 2.50e-02 GO:0005886 plasma membrane
2.39 2.53e-02 GO:0030016 myofibril
1.20 2.75e-02 GO:0071944 cell periphery
2.14 2.82e-02 GO:0070161 anchoring junction
2.36 4.60e-02 GO:0044449 contractile fiber part

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.03 4.68e-04 GO:0003779 actin binding
1.78 4.75e-04 GO:0008092 cytoskeletal protein binding